It may surprise you that orange peel has about four times more health benefits than the actual orange fruit. Orange peel contain flavonoids, like Polymethoxyflavones (PMFs) and hesperidin and other phytochemicals that have medicinal beneficial for your health.. Flavonoids are antioxidant compounds that help prevent chronic diseases such as cancer and heart diseases. It also contains higher amounts of certain nutrients.
3.5 ounces (about 100 grams) of orange peel provides 136 mg of Vitamin C. Also, orange peel contains considerable amounts of copper, calcium, magnesium, vitamin A and dietary fiber.
Some health benefits associated with orange peel:
Healthy Heart
Orange peels contain hesperidin, a flavonoid that helps maintain blood pressure and cholesterol. The polymethoxylated flavones (PMFs) found in orange peels also help lower cholesterol more effectively than drugs.

Prevent Allergies
Histamines are the chemicals that are responsible for allergic reactions. Orange peels contain compounds that can help prevent histamines release.
Prevent Cancer
Orange peels help slowly down growth of cancer cells. In fact, orange peels can reduce the number of squamous cell carcinoma, a fatal type of skin cancer. People who consume orange peels on a regular basis have less chances of being diagnosed with lung cancer and skin cancer than those who only eat the orange inside.
Weight loss
Orange peels help increase your metabolism and burn fat from your body. Many medical experts recommend orange peels as a cure to weight loss.
Better Digestion
Orange peels have anti-inflammatory properties that help treat many digestion and gastrointestinal problems such as diarrhea, heartburn and acidity.
Fights Infection, Cold and Flu
Orange peels are rich in vitamin C and A. This make orange peels a natural antioxidant that helps boost your immune system and fight off germs and viruses.

Treats skin problems
Orange peels help cure multiple skin problems such as blackheads, dead cells, acne, pores, dark circles and dry skin.
Source: Orange peel medicinal uses